Treatment of Hairy Cell Leukemia With Recombinant Alpha Interferon: I. Quantitative Study of Bone Marrow Changes
نویسندگان
چکیده
Seventeen patients with hairy cell leukemia (HCL) were treated with low doses of recombinant alpha interferon (IFN) for over 4 months. Marked improvement was observed in peripheral blood and bone marrow in 1 5 of 17 patients. Comparison of pretreatment values and hemograms obtained after 4 months of treatment showed a marked decrease in circulating hairy cells (P < .01 ). a decrease in the number of lymphocytes (P < .01 ). a rise in the number of platelets (P < .05). granulocytes (P < .05). and monocytes (P < .01 ). and a rise in the hemoglobin level (P < .01 ). Transient reduction in the number of granulocytes was noted during the first month. Correction of thrombocytopenia often appeared within 2 months and usually preceded improvement of anemia. monocytopenia. and neutropenia. Bone marrow biopsy specimens were taken before treatment and 2, 4. and 7 months after its initiation. The volumes occupied by hairy cells, cells of the
منابع مشابه
Treatment of hairy cell leukemia with recombinant alpha interferon: I. Quantitative study of bone marrow changes during the first months of treatment.
Seventeen patients with hairy cell leukemia (HCL) were treated with low doses of recombinant alpha interferon (IFN) for over 4 months. Marked improvement was observed in peripheral blood and bone marrow in 15 of 17 patients. Comparison of pretreatment values and hemograms obtained after 4 months of treatment showed a marked decrease in circulating hairy cells (P less than .01), a decrease in th...
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